GWAS reveal novel IgA nephropathy risk loci

IgA nephropathy, also known as Berger's disease, is the most common primary glomerulonephritis and a major cause of end stage renal disease (ESRD). IgA nephropathy typically presents as macroscopic haematuria (blood in the urine), often following a mucosal infection, and diagnosis is made based on a renal biopsy which shows deposition of IgA-containing immune complexes in the mesangial area of glomeruli and histopathological lesions such as mesang-ial cell proliferation and accumulation of extracellular matrix. It leads to progressive loss of kidney function and between 20 to 40% of cases will progress to ESRD within 20 years of disease onset [1]. There is substantial variation in prevalence of IgA nephropathy globally, with highest frequency in Asian populations, modest frequency in the European population and lowest frequency in the African population. These differences, together with evidence of familial clustering and renal abnormalities among relatives of cases, strongly suggest the presence of a substantial genetic contribution to disease development [1]. Genome-wide association studies (GWAS) have identified common variants within several loci (chromosomal regions) associated with IgA nephropathy risk. We conducted the most recent study, analyzing a total of 8,313 cases and 19,680 controls from the Han Chinese population across four stages [2]. This is the largest sample collection to date. Separately, a recent study by Kiryluk et al. analysed 7,658 cases and 12,954 controls, out of which 3,685 cases and 2,682 controls are East Asians and the rest are Europeans [3]. These two studies identified six novel loci over the previously identified five (namely 1q32 containing CFHR3-CFHR1 genes, 6p21 containing human leucocyte antigen class II genes, 8p23 containing the defensin gene cluster, 17p13.1 containing TNFSF13 and 22q12 containing HORMAD2), bringing the total to eleven [4,5]. We discovered novel associations at ST6GAL1 on 3q27.3, ACCS on 11p11.2 and ODF1-KLF10 on 8q22.3 [2], validated the recently reported association at ITGAX-ITGAM (16p11.2) and moderately replicate the reported associations at VAV3 (1p13) and CARD9 (9q34) [3]. Most of these loci, including two of our newly discovered ones ST6GAL1 and UBR5 (near ODF1-KLF10) implicate genes involved in innate immunity and IgA production, in particular mucosal immunity in the gut [2,3]. Several loci are shared with a variety of other autoimmune diseases [2,3]. The third locus harbouring the genes ACCS and EXT2 may implicate a new pathway involved in cell proliferation and heparan sulfate biosynthesis, which may influence the development of lesions in the kidneys, but further studies will …